Clin Chim Acta. 2003 Apr;330(1-2):165-71.
Anti-inflammatory effect of Lonicera japonica in proteinase-activated receptor 2-mediated paw edema.
Tae J, Han SW, Yoo JY, Kim JA, Kang OH, Baek OS, Lim JP, Kim DK, Kim YH, Bae KH, Lee YM.
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, South Korea.
BACKGROUND: Lonicera japonica (Caprifoliaceae) has long been used for treatment of infectious diseases. In the present study, the anti-inflammatory effects of L. japonica water extract (AELJ) were investigated in proteinase-activated receptor 2 (PAR2)-mediated mouse paw edema. METHODS: Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into hindpaw of mice. AELJ (10, 50, 100, and 200 mg/kg) was orally administered 1 h before induction of inflammation. RESULTS: At doses of 50, 100 and 200 mg/kg, the AELJ showed significant inhibition of both change in paw thickness and vascular permeability. The AELJ (100 mg/kg) also significantly inhibited PAR2 agonists-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue. CONCLUSION: The present study demonstrated that AELJ has an anti-inflammatory action for PAR2-mediated paw edema.
BOTANO GUARD + BOTANO THROAT:
Synergy for Faster Relief
of Lung Inflammation
BOTANO GUARD + IMMUNE REBALANCER:
Synergy for Faster Relief of Inflammation
Repairs Inflamed Throat
Desensitizes the Body to Allergens