Inhibitory Activity Against HIV-1 Protease (Reishi Mushroom)

Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Japan.

 

Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3 beta,7 beta-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid beta, (24S)-lanosta-7,9(11)-diene-3 beta,24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.

BOTANO GUARD:
Naturally Anti-Microbial
Anti-inflammatory

IMMUNE REBALANCER:
Naturally Anti-inflammatory
Desensitizes the Body to Allergens


BOTANO GUARD + IMMUNE REBALANCER:
Synergy for Faster Relief of Inflammation


BOTANO GUARD + BOTANO THROAT:
Synergy for Faster Relief
of Lung Inflammation


BOTANO THROAT:
Dissolves Mucus/Phlegm

Repairs Inflamed Throat


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