Antiviral and Immuno-Modulatory Activities (Chameleon Plant)

J Ethnopharmacol. 2008 Jun 19;118(1):79-85. Epub 2008 Mar 30.
Immunomodulatory and anti-SARS activities of Houttuynia cordata.
Lau KM, Lee KM, Koon CM, Cheung CS, Lau CP, Ho HM, Lee MY, Au SW, Cheng CH, Lau CB, Tsui SK, Wan DC, Waye MM, Wong KB, Wong CK, Lam CW, Leung PC, Fung KP.

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

 

ABSTRACT

BACKGROUND: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae)(HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. AIM OF THE STUDY: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects.

 

RESULTS: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4(+) and CD8(+) T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL(pro)) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16 g/kg.

 

CONCLUSION: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.

BOTANO GUARD:
Naturally Anti-Microbial
Anti-inflammatory

BOTANO GUARD + BOTANO THROAT:
Synergy for Faster Relief
of Lung Inflammation

BOTANO GUARD + IMMUNE REBALANCER:
Synergy for Faster Relief of Inflammation



BOTANO THROAT:
Dissolves Mucus/Phlegm

Repairs Inflamed Throat


IMMUNE REBALANCER:
Naturally Anti-inflammatory
Desensitizes the Body to  Allergens

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